Vaccine-Induced IgG Antibodies to V1V2 Regions of Multiple HIV-1 Subtypes Correlate with Decreased Risk of HIV-1 Infection

In the RV144 HIV-1 vaccine efficacy trial, IgG antibody (Ab) binding levels to variable regions 1 and 2 (V1V2) of the HIV-1 envelope glycoprotein gp120 were an inverse correlate of risk of HIV-1 infection. To determine if V1V2-specific Abs cross-react with V1V2 from different HIV-1 subtypes, if the...

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Autors principals: Zolla-Pazner, Susan, deCamp, Allan, Gilbert, Peter B., Williams, Constance, Yates, Nicole L., Williams, William T., Howington, Robert, Fong, Youyi, Morris, Daryl E., Soderberg, Kelly A., Irene, Carmela, Reichman, Charles, Pinter, Abraham, Parks, Robert, Pitisuttithum, Punnee, Kaewkungwal, Jaranit, Rerks-Ngarm, Supachai, Nitayaphan, Sorachai, Andrews, Charla, O’Connell, Robert J., Yang, Zhi-yong, Nabel, Gary J., Kim, Jerome H., Michael, Nelson L., Montefiori, David C., Liao, Hua-Xin, Haynes, Barton F., Tomaras, Georgia D.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3913641/
https://ncbi.nlm.nih.gov/pubmed/24504509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0087572
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