Interaction of purified type IIB von Willebrand factor with the platelet membrane glycoprotein Ib induces fibrinogen binding to the glycoprotein IIb/IIIa complex and initiates aggregation.

Von Willebrand factor (vWF) was purified from the plasma of a patient with type IIB von Willebrand disease (vWF from such a patient, IIB vWF) who had a normal platelet count and showed no evidence of spontaneous platelet aggregation. Large multimers of IIB vWF were absent from purified preparations...

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Bibliographic Details
Main Authors: De Marco, L, Girolami, A, Zimmerman, T S, Ruggeri, Z M
Format: Artigo
Language:Inglês
Published: 1985
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC391357/
https://ncbi.nlm.nih.gov/pubmed/2932740
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