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An allosteric Sec61 inhibitor traps nascent transmembrane helices at the lateral gate

Membrane protein biogenesis requires the coordinated movement of hydrophobic transmembrane domains (TMD) from the cytosolic vestibule of the Sec61 channel into the lipid bilayer. Molecular insight into TMD integration has been hampered by the difficulty of characterizing intermediates during this in...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: MacKinnon, Andrew L, Paavilainen, Ville O, Sharma, Ajay, Hegde, Ramanujan S, Taunton, Jack
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: eLife Sciences Publications, Ltd 2014
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3913039/
https://ncbi.nlm.nih.gov/pubmed/24497544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.01483
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