Polymorphism of the complement receptor 1 gene correlates with the hematologic response to eculizumab in patients with paroxysmal nocturnal hemoglobinuria

Complement blockade by eculizumab is clinically effective in hemolytic paroxysmal nocturnal hemoglobinuria. However, the response is variable and some patients remain dependent on red blood cell transfusions. In 72 patients with hemolytic paroxysmal nocturnal hemoglobinuria on eculizumab we tested t...

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Detalhes bibliográficos
Main Authors: Rondelli, Tommaso, Risitano, Antonio M., de Latour, Régis Peffault, Sica, Michela, Peruzzi, Benedetta, Ricci, Patrizia, Barcellini, Wilma, Iori, Anna Paola, Boschetti, Carla, Valle, Veronica, Frémeaux-Bacchi, Veronique, De Angioletti, Maria, Socie, Gerard, Luzzatto, Lucio, Notaro, Rosario
Formato: Artigo
Idioma:Inglês
Publicado em: Ferrata Storti Foundation 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3912955/
https://ncbi.nlm.nih.gov/pubmed/24038027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2013.090001
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