Polymorphism of the complement receptor 1 gene correlates with the hematologic response to eculizumab in patients with paroxysmal nocturnal hemoglobinuria

Complement blockade by eculizumab is clinically effective in hemolytic paroxysmal nocturnal hemoglobinuria. However, the response is variable and some patients remain dependent on red blood cell transfusions. In 72 patients with hemolytic paroxysmal nocturnal hemoglobinuria on eculizumab we tested t...

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Autors principals: Rondelli, Tommaso, Risitano, Antonio M., de Latour, Régis Peffault, Sica, Michela, Peruzzi, Benedetta, Ricci, Patrizia, Barcellini, Wilma, Iori, Anna Paola, Boschetti, Carla, Valle, Veronica, Frémeaux-Bacchi, Veronique, De Angioletti, Maria, Socie, Gerard, Luzzatto, Lucio, Notaro, Rosario
Format: Artigo
Idioma:Inglês
Publicat: Ferrata Storti Foundation 2014
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3912955/
https://ncbi.nlm.nih.gov/pubmed/24038027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2013.090001
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