Increased Tumor Ascorbate is Associated with Extended Disease-Free Survival and Decreased Hypoxia-Inducible Factor-1 Activation in Human Colorectal Cancer

Ascorbate is a co-factor for the hydroxylases that regulate the transcription factor hypoxia-inducible factor (HIF)-1, which provides cancer cells with a metabolic and survival advantage in the hypoxic environment of solid tumors. However, whether ascorbate affects tumor development is a highly deba...

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Detalhes bibliográficos
Main Authors: Kuiper, Caroline, Dachs, Gabi U., Munn, Delwyn, Currie, Margaret J., Robinson, Bridget A., Pearson, John F., Vissers, Margreet C. M.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2014
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3912592/
https://ncbi.nlm.nih.gov/pubmed/24551593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2014.00010
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