Proteomics Analysis of Co-Purifying Cellular Proteins Associated with rAAV Vectors

Recombinant adeno-associated vectors (rAAV) are commonly purified by either chromatography or equilibrium CsCl gradient. Nevertheless, even after purification various cellular proteins often associate with rAAV vector capsids. Such co-purifying cellular proteins may raise concern about safety of gen...

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Bibliografiske detaljer
Main Authors: Dong, Biao, Duan, Xunbao, Chow, Hoi Yee, Chen, Lingxia, Lu, Hui, Wu, Wenman, Hauck, Bernd, Wright, Fraser, Kapranov, Philipp, Xiao, Weidong
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3911921/
https://ncbi.nlm.nih.gov/pubmed/24498275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0086453
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