Efficient AAV1-AAV2 Hybrid Vector for Gene Therapy of Hemophilia

Adeno-associated virus (AAV) serotype 1 (AAV1) has been shown to be more effective than the well-studied AAV serotype 2 (AAV2) in muscle gene transfer. Replacement of amino acids 350 to 430 of AAV2 VP1 with the corresponding amino acids from VP1 of AAV1 resulted in a hybrid vector, termed AAV-221-IV...

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Main Authors: HAUCK, BERND, XU, RAY RUIAN, XIE, JING, WU, WENMAN, DING, QIULAN, SIPLER, MATTHEW, WANG, HONGLI, CHEN, LING, WRIGHT, J. FRASER, XIAO, WEIDONG
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2628442/
https://ncbi.nlm.nih.gov/pubmed/16409124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2006.17.46
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