Genomewide Mapping and Screening of Kaposi's Sarcoma-Associated Herpesvirus (KSHV) 3′ Untranslated Regions Identify Bicistronic and Polycistronic Viral Transcripts as Frequent Targets of KSHV MicroRNAs

Kaposi's sarcoma-associated herpesvirus (KSHV) encodes over 90 genes and 25 microRNAs (miRNAs). The KSHV life cycle is tightly regulated to ensure persistent infection in the host. In particular, miRNAs, which primarily exert their effects by binding to the 3′ untranslated regions (3′UTRs) of t...

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Détails bibliographiques
Auteurs principaux: Bai, Zhiqiang, Huang, Yufei, Li, Wan, Zhu, Ying, Jung, Jae U., Lu, Chun, Gao, Shou-Jiang
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2014
Sujets:
Genome Replication and Regulation of Viral Gene Expression
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3911756/
https://ncbi.nlm.nih.gov/pubmed/24155407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02689-13
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