Novel H7N9 Influenza Virus Shows Low Infectious Dose, High Growth Rate, and Efficient Contact Transmission in the Guinea Pig Model

The zoonotic outbreak of H7N9 subtype avian influenza virus that occurred in eastern China in the spring of 2013 resulted in 135 confirmed human cases, 44 of which were lethal. Sequencing of the viral genome revealed a number of molecular signatures associated with virulence or transmission in mamma...

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Main Authors: Gabbard, Jon D., Dlugolenski, Daniel, Van Riel, Debby, Marshall, Nicolle, Galloway, Summer E., Howerth, Elizabeth W., Campbell, Patricia J., Jones, Cheryl, Johnson, Scott, Byrd-Leotis, Lauren, Steinhauer, David A., Kuiken, Thijs, Tompkins, S. Mark, Tripp, Ralph, Lowen, Anice C., Steel, John
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2014
Teme:
Pathogenesis and Immunity
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3911619/
https://ncbi.nlm.nih.gov/pubmed/24227867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02959-13
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