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Highly Pathological Influenza A Virus Infection Is Associated with Augmented Expression of PD-1 by Functionally Compromised Virus-Specific CD8(+) T Cells

One question that continues to challenge influenza A research is why some strains of virus are so devastating compared to their more mild counterparts. We approached this question from an immunological perspective, investigating the CD8(+) T cell response in a mouse model system comparing high- and...

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Detalhes bibliográficos
Main Authors: Rutigliano, John A., Sharma, Shalini, Morris, Melissa Y., Oguin, Thomas H., McClaren, Jennifer L., Doherty, Peter C., Thomas, Paul G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3911576/
https://ncbi.nlm.nih.gov/pubmed/24257598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02851-13
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