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A new sea anemone peptide, APETx2, inhibits ASIC3, a major acid-sensitive channel in sensory neurons

From a systematic screening of animal venoms, we isolated a new toxin (APETx2) from the sea anemone Anthopleura elegantissima, which inhibits ASIC3 homomeric channels and ASIC3-containing heteromeric channels both in heterologous expression systems and in primary cultures of rat sensory neurons. APE...

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Détails bibliographiques
Auteurs principaux: Diochot, Sylvie, Baron, Anne, Rash, Lachlan D, Deval, Emmanuel, Escoubas, Pierre, Scarzello, Sabine, Salinas, Miguel, Lazdunski, Michel
Format: Artigo
Langue:Inglês
Publié: 2004
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC391081/
https://ncbi.nlm.nih.gov/pubmed/15044953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600177
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