Preclinical Characterization of GSK2336805, a Novel Inhibitor of Hepatitis C Virus Replication That Selects for Resistance in NS5A

GSK2336805 is an inhibitor of hepatitis C virus (HCV) with picomolar activity on the standard genotype 1a, 1b, and 2a subgenomic replicons and exhibits a modest serum shift. GSK2336805 was not active on 22 RNA and DNA viruses that were profiled. We have identified changes in the N-terminal region of...

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Detalhes bibliográficos
Main Authors: Walker, Jill, Crosby, Renae, Wang, Amy, Woldu, Ermias, Vamathevan, Jessica, Voitenleitner, Christian, You, Shihyun, Remlinger, Katja, Duan, Maoshang, Kazmierski, Wieslaw, Hamatake, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3910799/
https://ncbi.nlm.nih.gov/pubmed/24126581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01363-13
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