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GADD45β/GADD45γ and MEKK4 comprise a genetic pathway mediating STAT4-independent IFNγ production in T cells

The stress-inducible molecules GADD45β and GADD45γ have been implicated in regulating IFNγ production in CD4 T cells. However, how GADD45 proteins function has been controversial. MEKK4 is a MAP kinase kinase kinase that interacts with GADD45 in vitro. Here we generated MEKK4-deficient mice to defin...

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Autors principals: Chi, Hongbo, Lu, Binfeng, Takekawa, Mutsuhiro, Davis, Roger J, Flavell, Richard A
Format: Artigo
Idioma:Inglês
Publicat: 2004
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC391077/
https://ncbi.nlm.nih.gov/pubmed/15044949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600173
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