GADD45β/GADD45γ and MEKK4 comprise a genetic pathway mediating STAT4-independent IFNγ production in T cells

The stress-inducible molecules GADD45β and GADD45γ have been implicated in regulating IFNγ production in CD4 T cells. However, how GADD45 proteins function has been controversial. MEKK4 is a MAP kinase kinase kinase that interacts with GADD45 in vitro. Here we generated MEKK4-deficient mice to defin...

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Bibliographic Details

Published in:	EMBO J
Main Authors:	Chi, Hongbo, Lu, Binfeng, Takekawa, Mutsuhiro, Davis, Roger J, Flavell, Richard A
Format:	Artigo
Language:	Inglês
Published:	Nature Publishing Group 2004
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC391077/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15044949/ https://ncbi.nlm.nih.govhttps://doi.org/10.1038/sj.emboj.7600173
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