Hepatotoxicity of Pentavalent Antimonial Drug: Possible Role of Residual Sb(III) and Protective Effect of Ascorbic Acid

Pentavalent antimonial drugs such as meglumine antimoniate (Glucantime [Glu; Sanofi-Aventis, São Paulo, Brazil]) produce severe side effects, including cardiotoxicity and hepatotoxicity, during the treatment of leishmaniasis. We evaluated the role of residual Sb(III) in the hepatotoxicity of meglumi...

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Autors principals: Kato, Kelly C., Morais-Teixeira, Eliane, Reis, Priscila G., Silva-Barcellos, Neila M., Salaün, Pascal, Campos, Paula P., Dias Corrêa-Junior, José, Rabello, Ana, Demicheli, Cynthia, Frézard, Frédéric
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2014
Matèries:
Experimental Therapeutics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3910754/
https://ncbi.nlm.nih.gov/pubmed/24189251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01499-13
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