Efficacy of Meglumine Antimoniate in a Low Polymerization State Orally Administered in a Murine Model of Visceral Leishmaniasis

Progress toward the improvement of meglumine antimoniate (MA), commercially known as Glucantime, a highly effective but also toxic antileishmanial drug, has been hindered by the lack of knowledge and control of its chemical composition. Here, MA was manipulated chemically with the aim of achieving a...

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Bibliographische Detailangaben
Veröffentlicht in:Antimicrob Agents Chemother
Hauptverfasser: Kato, Kelly C., de Morais-Teixeira, Eliane, Islam, Arshad, Leite, M. Fatima, Demicheli, Cynthia, de Castro, Whocely V., Corrêa-Junior, José D., Rabello, Ana, Frézard, Frédéric
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2018
Schlagworte:
Experimental Therapeutics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6105864/
https://ncbi.nlm.nih.gov/pubmed/29866873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00539-18
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