Efficacy of Meglumine Antimoniate in a Low Polymerization State Orally Administered in a Murine Model of Visceral Leishmaniasis

Progress toward the improvement of meglumine antimoniate (MA), commercially known as Glucantime, a highly effective but also toxic antileishmanial drug, has been hindered by the lack of knowledge and control of its chemical composition. Here, MA was manipulated chemically with the aim of achieving a...

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Dades bibliogràfiques
Publicat a:Antimicrob Agents Chemother
Autors principals: Kato, Kelly C., de Morais-Teixeira, Eliane, Islam, Arshad, Leite, M. Fatima, Demicheli, Cynthia, de Castro, Whocely V., Corrêa-Junior, José D., Rabello, Ana, Frézard, Frédéric
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2018
Matèries:
Experimental Therapeutics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6105864/
https://ncbi.nlm.nih.gov/pubmed/29866873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00539-18
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