Efficacy of Meglumine Antimoniate in a Low Polymerization State Orally Administered in a Murine Model of Visceral Leishmaniasis

Progress toward the improvement of meglumine antimoniate (MA), commercially known as Glucantime, a highly effective but also toxic antileishmanial drug, has been hindered by the lack of knowledge and control of its chemical composition. Here, MA was manipulated chemically with the aim of achieving a...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Kato, Kelly C., de Morais-Teixeira, Eliane, Islam, Arshad, Leite, M. Fatima, Demicheli, Cynthia, de Castro, Whocely V., Corrêa-Junior, José D., Rabello, Ana, Frézard, Frédéric
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6105864/
https://ncbi.nlm.nih.gov/pubmed/29866873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00539-18
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