The myxobacterial metabolite ratjadone A inhibits HIV infection by blocking the Rev/CRM1-mediated nuclear export pathway

BACKGROUND: The nuclear export of unspliced and partially spliced HIV-1 mRNA is mediated by the recognition of a leucine-rich nuclear export signal (NES) in the HIV Rev protein by the host protein CRM1/Exportin1. This makes the CRM1-Rev complex an attractive target for the development of new antivir...

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Библиографические подробности
Главные авторы: Fleta-Soriano, Eric, Martinez, Javier P, Hinkelmann, Bettina, Gerth, Klaus, Washausen, Peter, Diez, Juana, Frank, Ronald, Sasse, Florenz, Meyerhans, Andreas
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2014
Предметы:
Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3910686/
https://ncbi.nlm.nih.gov/pubmed/24475978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2859-13-17
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