The Myxobacterial Metabolite Soraphen A Inhibits HIV-1 by Reducing Virus Production and Altering Virion Composition

Soraphen A is a myxobacterial metabolite that blocks the acetyl-coenzyme A carboxylase of the host and was previously identified as a novel HIV inhibitor. Here, we report that soraphen A acts by reducing virus production and altering the gp120 virion content, impacting entry capacity and infectivity...

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Publicado en:Antimicrob Agents Chemother
Autores principales: Fleta-Soriano, Eric, Smutná, Katarína, Martínez, Javier P., Lorca Oró, Cristina, Sadiq, S. Kashif, Mirambeau, Gilles, Lopez-Iglesias, Carmen, Bosch, Marta, Pol, Albert, Brönstrup, Mark, Diez, Juana, Meyerhans, Andreas
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2017
Materias:
Antiviral Agents
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5527598/
https://ncbi.nlm.nih.gov/pubmed/28533249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00739-17
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