Reducing virulence of the human pathogen Burkholderia by altering the substrate specificity of the quorum-quenching acylase PvdQ

The use of enzymes to interfere with quorum sensing represents an attractive strategy to fight bacterial infections. We used PvdQ, an effective quorum-quenching enzyme from Pseudomonas aeruginosa, as a template to generate an acylase able to effectively hydrolyze C8-HSL, the major communication mole...

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Autori principali: Koch, Gudrun, Nadal-Jimenez, Pol, Reis, Carlos R., Muntendam, Remco, Bokhove, Marcel, Melillo, Elena, Dijkstra, Bauke W., Cool, Robbert H., Quax, Wim J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2014
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3910591/
https://ncbi.nlm.nih.gov/pubmed/24474783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1311263111
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