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Quorum-Quenching Acylase Reduces the Virulence of Pseudomonas aeruginosa in a Caenorhabditis elegans Infection Model

The Pseudomonas aeruginosa PAO1 gene pvdQ encodes an acyl-homoserine lactone (AHL) acylase capable of degrading N-(3-oxododecanoyl)-l-homoserine lactone by cleaving the AHL amide. PvdQ has been proven to function as a quorum quencher in vitro in a number of phenotypic assays. To address the question...

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Autors principals: Papaioannou, Evelina, Wahjudi, Mariana, Nadal-Jimenez, Pol, Koch, Gudrun, Setroikromo, Rita, Quax, Wim J.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2772301/
https://ncbi.nlm.nih.gov/pubmed/19721066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00380-09
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