Isocitrate Dehydrogenase-1 Mutations as Prognostic Biomarker in Glioblastoma Multiforme Patients in West Bohemia

Introduction. Glioblastoma multiforme (GBM) is the most malignant primary brain tumor in adults. Recent whole-genome studies revealed novel GBM prognostic biomarkers such as mutations in metabolic enzyme IDH—isocitrate dehydrogenases (IDH1 and IDH2). The distinctive mutation IDH1 R132H was uncovered...

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Autors principals: Polivka, J., Rohan, V., Pesta, M., Repik, T., Pitule, P., Topolcan, O.
Format: Artigo
Idioma:Inglês
Publicat: Hindawi Publishing Corporation 2014
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3910481/
https://ncbi.nlm.nih.gov/pubmed/24511544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/735659
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