D-polyglutamine amyloid recruits L-polyglutamine monomers and kills cells

Polyglutamine (polyQ) amyloid fibrils are observed in disease tissue and have been implicated as toxic agents responsible for neurodegeneration in expanded CAG repeat diseases like Huntington’s disease (HD). Despite intensive efforts, the mechanism of amyloid toxicity remains unknown. As a novel app...

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Detaylı Bibliyografya
Asıl Yazarlar: Kar, Karunakar, Arduini, Irene, Drombosky, Kenneth W., van der Wel, Patrick C. A., Wetzel, Ronald
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2013
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3910295/
https://ncbi.nlm.nih.gov/pubmed/24291210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2013.11.019
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