Assay Platform for Clinically Relevant Metallo-β-lactamases

[Image: see text] Metallo-β-lactamases (MBLs) are a growing threat to the use of almost all clinically used β-lactam antibiotics. The identification of broad-spectrum MBL inhibitors is hampered by the lack of a suitable screening platform, consisting of appropriate substrates and a set of clinically...

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Auteurs principaux: van Berkel, Sander S., Brem, Jürgen, Rydzik, Anna M., Salimraj, Ramya, Cain, Ricky, Verma, Anil, Owens, Raymond J., Fishwick, Colin W. G., Spencer, James, Schofield, Christopher J.
Format: Artigo
Langue:Inglês
Publié: American Chemical Society 2013
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3910272/
https://ncbi.nlm.nih.gov/pubmed/23898798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm400769b
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