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Bacterial toxin RelE: A highly efficient nuclease with exquisite substrate specificity using atypical catalytic residues

The toxin RelE is a ribosome-dependent endoribonuclease implicated in diverse cellular processes, including persistence. During amino acid starvation, RelE inhibits translation by cleaving ribosomal A-site mRNA. Although RelE is structurally similar to other microbial endoribonucleases, the active-s...

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Bibliografiske detaljer
Main Authors: Griffin, Meghan A., Davis, Jared H., Strobel, Scott A.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3910103/
https://ncbi.nlm.nih.gov/pubmed/24251350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi401325c
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