Isolation and biochemical and functional characterization of perforin 1 from cytolytic T-cell granules.
The Ca2+-dependent cytolytic activity of isolated T-lymphocyte granules was purified to apparent homogeneity by high-salt extraction, gel filtration, and ion-exchange chromatography. The lytic activity resided in a 72- to 75-kDa protein of cytolytic granules. Incubation of the isolated protein with...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
1985
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC390971/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2417226/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.82.24.8629 |
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