Isolation and biochemical and functional characterization of perforin 1 from cytolytic T-cell granules.

The Ca2+-dependent cytolytic activity of isolated T-lymphocyte granules was purified to apparent homogeneity by high-salt extraction, gel filtration, and ion-exchange chromatography. The lytic activity resided in a 72- to 75-kDa protein of cytolytic granules. Incubation of the isolated protein with...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Podack, E R, Young, J D, Cohn, Z A
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1985
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC390971/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2417226/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.82.24.8629
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