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Daunomycin, an antitumor DNA intercalator, influences histone–DNA interactions

Although daunomycin and adriamycin are considered effective antitumor drugs and have been used in the clinic for over 40 years, their mechanism of action is still a matter of debate. We investigated the influence of daunomycin on interaction between linker or core histones and DNA in live HeLa cells...

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Detalhes bibliográficos
Main Authors: Wójcik, Krzysztof, Zarębski, Mirosław, Cossarizza, Andrea, Dobrucki, Jurek W
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3909551/
https://ncbi.nlm.nih.gov/pubmed/23792590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.25328
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