Stabilized complexes of epidermal growth factor and its receptor on the cell surface stimulate RNA synthesis but not mitogenesis.
Treatment of mouse fibroblasts, prelabeled at 4 degrees C with 125I-labeled epidermal growth factor (EGF), with the lectin concanavalin A (Con A) stabilized the 125I-labeled EGF-receptor complex to dissociation and prevented receptor-mediated endocytosis; after 5 hr at 37 degrees C, approximately 50...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Principais autores: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
1985
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC390946/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2417223/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.82.24.8513 |
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