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Microbial synthesized biodegradable PHBHHxPEG hybrid copolymer as an efficient intracellular delivery nanocarrier for kinase inhibitor

BACKGROUND: Protein Kinases are key regulators of cell function and play essential roles in the occurrence and development of many human diseases. Many kinase inhibitors have been used for molecular targeted treatment of those diseases such as cancer and inflammation. However, those highly hydrophob...

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Main Authors: Lu, Xiao-Yun, Li, Ming-Chuan, Zhu, Xin-Liang, Fan, Fan, Wang, Lei-Lei, Ma, Jian-Gang
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3909372/
https://ncbi.nlm.nih.gov/pubmed/24438107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6750-14-4
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