PEG–Polypeptide Block Copolymers as pH-Responsive Endosome-Solubilizing Drug Nanocarriers

[Image: see text] Herein we report the potential of click chemistry-modified polypeptide-based block copolymers for the facile fabrication of pH-sensitive nanoscale drug delivery systems. PEG–polypeptide copolymers with pendant amine chains were synthesized by combining N-carboxyanhydride-based ring...

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Detalhes bibliográficos
Main Authors: Quadir, Mohiuddin A., Morton, Stephen W., Deng, Zhou J., Shopsowitz, Kevin E., Murphy, Ryan P., Epps, Thomas H., Hammond, Paula T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4096223/
https://ncbi.nlm.nih.gov/pubmed/24813025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp500162w
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