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Effects of phospholipids and ADP-ribosylation on GTP hydrolysis by Escherichia coli-synthesized Ha-ras-encoded p21.

The Ha-ras protooncogene product p21, which may be involved in control of cellular growth, is a membrane protein that binds guanine nucleotides and hydrolyzes GTP. p21 GTPase activity is stimulated by lysophosphatidylcholine; a delay in activation was observed unless p21 was incubated with the phosp...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Tsai, S C, Adamik, R, Moss, J, Vaughan, M, Manne, V, Kung, H F
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 1985
Subjects:
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC390905/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3001695/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.82.24.8310
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