Structural basis for the inhibitory effect of brefeldin A on guanine nucleotide-exchange proteins for ADP-ribosylation factors

Protein secretion through the endoplasmic reticulum and Golgi vesicular trafficking system is initiated by the binding of ADP-ribosylation factors (ARFs) to donor membranes, leading to recruitment of coatomer, bud formation, and eventual vesicle release. ARFs are ≈20-kDa GTPases that are active with...

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Bibliographic Details
Main Authors: Sata, Makoto, Moss, Joel, Vaughan, Martha
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 1999
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC15841/
https://ncbi.nlm.nih.gov/pubmed/10077583
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