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Structural basis for the inhibitory effect of brefeldin A on guanine nucleotide-exchange proteins for ADP-ribosylation factors

Protein secretion through the endoplasmic reticulum and Golgi vesicular trafficking system is initiated by the binding of ADP-ribosylation factors (ARFs) to donor membranes, leading to recruitment of coatomer, bud formation, and eventual vesicle release. ARFs are ≈20-kDa GTPases that are active with...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Sata, Makoto, Moss, Joel, Vaughan, Martha
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1999
Fag:
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC15841/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10077583/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.6.2752
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