Loss of Hypoxia-Inducible Factor 2 Alpha in the Lung Alveolar Epithelium of Mice Leads to Enhanced Eosinophilic Inflammation in Cobalt-Induced Lung Injury

Hard metal lung disease (HMLD) is an occupational lung disease specific to inhalation of cobalt-containing particles whose mechanism is largely unknown. Cobalt is a known hypoxia mimic and stabilizer of the alpha subunits of hypoxia-inducible factors (HIFs). Previous work revealed that though HIF1α...

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Main Authors: Proper, Steven P., Saini, Yogesh, Greenwood, Krista K., Bramble, Lori A, Downing, Nathaniel J., Harkema, Jack R., LaPres, John J.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2014
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3908723/
https://ncbi.nlm.nih.gov/pubmed/24218148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kft253
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