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The Extent of Protease Resistance of Misfolded Prion Protein Is Highly Dependent on the Salt Concentration
Transmissible spongiform encephalopathies are neurodegenerative diseases caused by prions in mammals. An aberrantly folded protein (PrP(Sc)) is the main component of these proteinaceous infectious particles. Prions exhibit strong resistance to protease digestion, which is typically exploited for bio...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3908437/ https://ncbi.nlm.nih.gov/pubmed/24338008 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.513267 |
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