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Length variants of the 5′ untranslated region of p53 mRNA and their impact on the efficiency of translation initiation of p53 and its N-truncated isoform ΔNp53

Recently, we have determined the secondary structure of the 5′-terminal region of p53 mRNA that starts from the P1 transcription initiation site and includes two major translation initiation codons responsible for the synthesis of p53 and ΔNp53 isoform. Here, we showed that when this region was exte...

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Detalhes bibliográficos
Main Authors: Górska, Agnieszka, Błaszczyk, Leszek, Dutkiewicz, Mariola, Ciesiołka, Jerzy
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3907482/
https://ncbi.nlm.nih.gov/pubmed/24418891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/rna.26562
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