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Modulation of p53 Expression Using Antisense Oligonucleotides Complementary to the 5′-Terminal Region of p53 mRNA In Vitro and in the Living Cells

The p53 protein is a key player in cell response to stress events and cancer prevention. However, up-regulation of p53 that occurs during radiotherapy of some tumours results in radio-resistance of targeted cells. Recently, antisense oligonucleotides have been used to reduce the p53 level in tumour...

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Autori principali: Gorska, Agnieszka, Swiatkowska, Agata, Dutkiewicz, Mariola, Ciesiolka, Jerzy
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3824000/
https://ncbi.nlm.nih.gov/pubmed/24244378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0078863
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