A conformational switch in HP1 releases auto-inhibition to drive heterochromatin assembly

A hallmark of histone H3 lysine 9 (H3K9) methylated heterochromatin, conserved from fission yeast,Schizosaccharomyces pombe (S. pombe), to humans, is its ability to spread to adjacent genomic regions(1–6). Central to heterochromatin spread is the heterochromatin protein 1 (HP1), which recognizes H3K...

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Autors principals: Canzio, Daniele, Liao, Maofu, Naber, Nariman, Pate, Ed, Larson, Adam, Wu, Shenping, Marina, Diana B., Garcia, Jennifer F., Madhani, Hiten D., Cooke, Roger, Schuck, Peter, Cheng, Yifan, Narlikar, Geeta J.
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3907283/
https://ncbi.nlm.nih.gov/pubmed/23485968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature12032
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