Bayesian Total Internal Reflection Fluorescence Correlation Spectroscopy Reveals hIAPP-Induced Plasma Membrane Domain Organization in Live Cells

Amyloid fibril deposition of human islet amyloid polypeptide (hIAPP) in pancreatic islet cells is implicated in the pathogenesis of type II diabetes. A growing number of studies suggest that small peptide aggregates are cytotoxic via their interaction with the plasma membrane, which leads to membran...

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Autores principales: Guo, Syuan-Ming, Bag, Nirmalya, Mishra, Aseem, Wohland, Thorsten, Bathe, Mark
Formato: Artigo
Lenguaje:Inglês
Publicado: The Biophysical Society 2014
Materias:
Membranes
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3907249/
https://ncbi.nlm.nih.gov/pubmed/24411251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2013.11.4458
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