Analgesic tolerance of opioid agonists in mutant mu-opioid receptors expressed in sensory neurons following intrathecal plasmid gene delivery

BACKGROUND: Phosphorylation sites in the C-terminus of mu-opioid receptors (MORs) are known to play critical roles in the receptor functions. Our understanding of their participation in opioid analgesia is mostly based on studies of opioid effects on mutant receptors expressed in in vitro preparatio...

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Autori principali: Li, Guangwen, Ma, Fei, Gu, Yanping, Huang, Li-Yen Mae
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2013
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3906983/
https://ncbi.nlm.nih.gov/pubmed/24304623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-8069-9-63
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