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Critical Role of the mTOR Pathway in Development and Function of Myeloid-Derived Suppressor Cells in lal(−/−) Mice

Lysosomal acid lipase (LAL) is essential for the hydrolysis of cholesteryl esters and triglycerides to generate cholesterol and free fatty acids in cellular lysosomes. Ablation of the lal gene (lal(−/−)) systemically increased expansion of cluster of differentiation molecule 11b (CD11b), lymphocyte...

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Detalhes bibliográficos
Main Authors: Ding, Xinchun, Du, Hong, Yoder, Mervin C., Yan, Cong
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3906486/
https://ncbi.nlm.nih.gov/pubmed/24287405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2013.10.015
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