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Critical Role of the mTOR Pathway in Development and Function of Myeloid-Derived Suppressor Cells in lal(−/−) Mice
Lysosomal acid lipase (LAL) is essential for the hydrolysis of cholesteryl esters and triglycerides to generate cholesterol and free fatty acids in cellular lysosomes. Ablation of the lal gene (lal(−/−)) systemically increased expansion of cluster of differentiation molecule 11b (CD11b), lymphocyte...
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| 主要な著者: | , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Investigative Pathology
2014
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3906486/ https://ncbi.nlm.nih.gov/pubmed/24287405 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2013.10.015 |
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