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Critical Role of the mTOR Pathway in Development and Function of Myeloid-Derived Suppressor Cells in lal(−/−) Mice
Lysosomal acid lipase (LAL) is essential for the hydrolysis of cholesteryl esters and triglycerides to generate cholesterol and free fatty acids in cellular lysosomes. Ablation of the lal gene (lal(−/−)) systemically increased expansion of cluster of differentiation molecule 11b (CD11b), lymphocyte...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Investigative Pathology
2014
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3906486/ https://ncbi.nlm.nih.gov/pubmed/24287405 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2013.10.015 |
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