Vaccination with Vaxfectin(®) adjuvanted SIV DNA induces long-lasting humoral immune responses able to reduce SIVmac251 Viremia

We evaluated the immunogenicity and efficacy of Vaxfectin(®) adjuvanted SIV DNA vaccines in mice and macaques. Vaccination of mice with Vaxfectin(®) adjuvanted SIV gag DNA induced higher humoral immune responses than administration of unadjuvanted DNA, whereas similar levels of cellular immunity wer...

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Autors principals: Kulkarni, Viraj, Rosati, Margherita, Valentin, Antonio, Jalah, Rashmi, Alicea, Candido, Yu, Lei, Guan, Yongjun, Shen, Xiaoying, Tomaras, Georgia D, LaBranche, Celia, Montefiori, David C, Irene, Carmela, Prattipati, Rajasekhar, Pinter, Abraham, Sullivan, Sean M, Pavlakis, George N, Felber, Barbara K
Format: Artigo
Idioma:Inglês
Publicat: Landes Bioscience 2013
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3906391/
https://ncbi.nlm.nih.gov/pubmed/23820294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/hv.25442
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