Cyclin-dependent kinase 4 may be expressed as multiple proteins and have functions that are independent of binding to CCND and RB and occur at the S and G(2)/M phases of the cell cycle

Cyclin-dependent kinase 4 (CDK4) is known to be a 33 kD protein that drives G(1) phase progression of the cell cycle by binding to a CCND protein to phosphorylate RB proteins. Using different CDK4 antibodies in western blot, we detected 2 groups of proteins around 40 and 33 kD, respectively, in huma...

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Detalhes bibliográficos
Main Authors: Sun, Yuan, Lou, Xiaomin, Yang, Min, Yuan, Chengfu, Ma, Ling, Xie, Bing-Kun, Wu, Jian-min, Yang, Wei, Shen, Steven XJ, Xu, Ningzhi, Liao, D Joshua
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3906337/
https://ncbi.nlm.nih.gov/pubmed/24091631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.26510
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