Influence of FCGRT gene polymorphisms on pharmacokinetics of therapeutic antibodies

The neonatal Fc receptor (FcRn) encoded by FCGRT is known to be involved in the pharmacokinetics (PK) of therapeutic monoclonal antibodies (mAbs). Variability in the expression of FCGRT gene and consequently in the FcRn protein level could explain differences in PK observed between patients treated...

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Detalhes bibliográficos
Main Authors: Passot, Christophe, Azzopardi, Nicolas, Renault, Sylvaine, Baroukh, Nadine, Arnoult, Christophe, Ohresser, Marc, Boisdron-Celle, Michèle, Gamelin, Erick, Watier, Hervé, Paintaud, Gilles, Gouilleux-Gruart, Valérie
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3906315/
https://ncbi.nlm.nih.gov/pubmed/23751752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.24815
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