Influence of FCGRT gene polymorphisms on pharmacokinetics of therapeutic antibodies

The neonatal Fc receptor (FcRn) encoded by FCGRT is known to be involved in the pharmacokinetics (PK) of therapeutic monoclonal antibodies (mAbs). Variability in the expression of FCGRT gene and consequently in the FcRn protein level could explain differences in PK observed between patients treated...

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Bibliografische gegevens
Hoofdauteurs: Passot, Christophe, Azzopardi, Nicolas, Renault, Sylvaine, Baroukh, Nadine, Arnoult, Christophe, Ohresser, Marc, Boisdron-Celle, Michèle, Gamelin, Erick, Watier, Hervé, Paintaud, Gilles, Gouilleux-Gruart, Valérie
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Landes Bioscience 2013
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3906315/
https://ncbi.nlm.nih.gov/pubmed/23751752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.24815
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