Expression of antibodies using single open reading frame (sORF) vector design: Demonstration of manufacturing feasibility

Efficient production of large quantities of therapeutic antibodies is becoming a major goal of the pharmaceutical industry. We developed a proprietary expression system using a polyprotein precursor-based approach to antibody expression in mammalian cells. In this approach, the coding regions for he...

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Hlavní autoři: Gion, Wendy R., Davis-Taber, Rachel A., Regier, Dean A., Fung, Emma, Medina, Limary, Santora, Ling C., Bose, Sahana, Ivanov, Alexander V., Perilli-Palmer, Barbara A., Chumsae, Chris M., Matuck, Joseph G., Kunes, Yune Z., Carson, Gerald R.
Médium: Artigo
Jazyk:Inglês
Vydáno: Landes Bioscience 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3906313/
https://ncbi.nlm.nih.gov/pubmed/23774760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.25161
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