Characterization of a surrogate murine antibody to model anti-human CD3 therapies

Fc-modified anti-human CD3ε monoclonal antibodies (mAbs) are in clinical development for the treatment of autoimmune diseases. These next generation mAbs have completed clinical trials in patients with type-1 diabetes and inflammatory bowel disease demonstrating a narrow therapeutic window. Lowered...

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Main Authors: Dépis, Fabien, Hatterer, Eric, Ballet, Romain, Daubeuf, Bruno, Cons, Laura, Glatt, Sophie, Reith, Walter, Kosco-Vilbois, Marie, Dean, Yann
Format: Artigo
Sprog:Inglês
Udgivet: Landes Bioscience 2013
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Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3906309/
https://ncbi.nlm.nih.gov/pubmed/23751612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.24736
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