Immunotherapeutic efficiency of a tetravalent Aβ1-15 vaccine in APP/PS1 transgenic mice as mouse model for Alzheimer’s disease

Immunization with synthetic, preaggregated β-amyloid (Aβ) was the first treatment approach able to dramatically reduce brain Aβ pathology in Alzheimer’s disease (AD) animal models. For the development of a safe vaccine, we investigated whether 4Aβ1-15 (four tandem repeats of GPGPG-linked Aβ1-15 sequ...

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Библиографические подробности
Главные авторы: Guan, Xiaoying, Yang, Junhua, Gu, Huaiyu, Zou, Juntao, Yao, Zhibin
Формат: Artigo
Язык:Inglês
Опубликовано: Landes Bioscience 2013
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Research Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3906261/
https://ncbi.nlm.nih.gov/pubmed/23732905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/hv.24830
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