Immunotherapeutic efficiency of a tetravalent Aβ1-15 vaccine in APP/PS1 transgenic mice as mouse model for Alzheimer’s disease

Immunization with synthetic, preaggregated β-amyloid (Aβ) was the first treatment approach able to dramatically reduce brain Aβ pathology in Alzheimer’s disease (AD) animal models. For the development of a safe vaccine, we investigated whether 4Aβ1-15 (four tandem repeats of GPGPG-linked Aβ1-15 sequ...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Guan, Xiaoying, Yang, Junhua, Gu, Huaiyu, Zou, Juntao, Yao, Zhibin
Médium: Artigo
Jazyk:Inglês
Vydáno: Landes Bioscience 2013
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3906261/
https://ncbi.nlm.nih.gov/pubmed/23732905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/hv.24830
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky