Allo-Reactivity of Mesenchymal Stem Cells in Rhesus Macaques Is Dose and Haplotype Dependent and Limits Durable Cell Engraftment In Vivo

The emerging paradigm that MSCs are immune privileged has fostered the use of “off-the-shelf” allogeneic MSC-based therapies in human clinical trials. However, this approach ignores studies in experimental animals wherein transplantation of MSCs across MHC boundaries elicits measurable allo-immune r...

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Bibliographic Details
Main Authors: Isakova, Iryna A., Lanclos, Calvin, Bruhn, Julie, Kuroda, Marcelo J., Baker, Kate C., Krishnappa, Veena, Phinney, Donald G.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3906169/
https://ncbi.nlm.nih.gov/pubmed/24489878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0087238
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